Our research group recently identified a genetic defect that causes the accumulation of lipids in the pulmonary alveoli. New discovery on the causes of PAP lung disease can also offer solutions for treating obesity and heart disease.

Pulmonary alveoli are tiny bubble-like air sacs at the end of bronchial tubes. They are vital for survival as they exchange oxygen for carbon dioxide.

The alveoli are covered by a thin fluid film called surfactant which consists mainly of lipids. Surfactant does not only protect the lungs against airborne pathogens and dust, but also facilitates proper respiration by reducing the alveolar surface tension.